Nano bios programmer software9/23/2023 ![]() Credit: Science Advances, doi: 10.1126/sciadv.aau2124 A kinetics plot is obtained by cumulatively counting the number of state-switching receptors over time. Receptor-only snapshots (top) and a kinetics plot (bottom) of the Assembly YES gate are provided for each input condition. Afterward, the detected signals are sampled and used to generate a new dark-field movie that visualizes only receptor signals. A single-particle tracking algorithm first identifies receptor signals from a raw image sequence. Glowing circles behind R–F dimers illustrate plasmonic coupling. Functional domains are represented by color and subscripted numbers with arrowheads indicating their 3′ ends. Bidirectional arrows denote R–F interactions. ![]() Each logic gate takes DNA as inputs and yields either an assembly or a disassembly between the two particles as an output. (B) R–F pairs as nanoparticle Boolean logic gates. Two types of DNA-modified nanoparticles, immobile receptor (R) and mobile floater (F), are tethered to an SLB and monitored by DFM. Single-nanoparticle logic computation on LNTs.
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